Rauwolfia Serpentina Ameliorates Hyperglycemic, Haematinic and Antioxidant Status in Alloxan- Induced Diabetic Mice.
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Date
2013-07
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Abstract
To investigate the effect of methanolic root extract (MREt) of Rauwolfia serpentina on hyperglycemic,
haematinic and antioxidative dysfunction associated with alloxan-induced diabetes. Mice were divided into
normal and alloxan-induced diabetic groups, the second group was sub-divided into three MREt (10, 30 &
60mg/kg) treated test groups and three diabetic (distilled water 1ml/kg), negative (0.05% dimethyl sulphoxide
1ml/kg) and positive (glibenclamide 5mg/kg) control groups. Each treatment was done orally for 14 days. The
MREt significantly reduced blood glucose level by improving the body weights, glycosylated hemoglobin
(HbA1c) to total hemoglobin (Hb) ratio, red blood cell (RBC) & white blood cell (WBC) counts, packed cell
volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular
hemoglobin concentration (MCHC) in test groups. Beside this, extract decreases the percent inhibition of catalase
(CAT) & superoxide dismutase (SOD) enzymes and restores the liver function by recovering the total protein
concentration and normalizing the levels of alanine transaminase (ALT), aspartate transaminase (AST) &
alkaline phosphatase (ALP) in test mice. Therefore, MREt ameliorates hyperglycemic, haematinic and
antioxidant status in alloxan-induced diabetic mice. Further work is still required to find out the active principle
in same extract involved in antidiabetic activity.
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Keywords
antioxidant enzymes, complete blood profile, hyperglycemia, Rauwolfia serpentina
Citation
Azmi Muhammad Bilal, Qureshi Shamim A. Rauwolfia Serpentina Ameliorates Hyperglycemic, Haematinic and Antioxidant Status in Alloxan- Induced Diabetic Mice. Journal of Applied Pharmaceutical Science. 2013 July; 3(7): 136-141.