New Halogenated Thiosemicarbazones as Potential Antimicrobial Agents: synthesis and spectral characterization.
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Date
2013-07
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Abstract
Three new chalcogenic thiosemicarbazones (3,4-difluoroacetophenone thiosemicarbazone(1), 2-bromo-4’-
chloroacetophenone thiosemicarbazone(2) and 2, 4’-dibromoacetophenone thiosemicarbazone(3) are synthesized
by using a conventional one step processes in which the respective halo-substituted acetophenones are condensed
with thiosemicarbazide to result in the formation of the product. The chalcogenic thiosemicarbazones are then
characterized by the spectroscopic techniques like FT-IR, FT-Raman, UV-Vis, 1H and 13C NMR (19F for 1), HRMS
and LC-MS, TG-DTA. The compound 1 is unambiguously characterized by single crystal X-ray diffraction
and is found to have monoclinic system. These compounds were further tested for their antimicrobial activity
against some human pathogens like E. coli, B. subtilis, P. aureginosa and S. aureus. The MIC values have
suggested that these are potential antimicrobial agents.
Description
Keywords
Chalcogenic, thiosemicarbazones, sulphur organic compounds, antimicrobial activity
Citation
Jagadeesh M, Kumar V Asha, Ramachandraiah C, Reddy A Varada. New Halogenated Thiosemicarbazones as Potential Antimicrobial Agents: synthesis and spectral characterization. Journal of Applied Pharmaceutical Science. 2013 July; 3(7): 111-115.