Characterization and Optimization of Natural Maltodextrin-based Niosome.
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Date
2013-07
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Abstract
Natural maltodextrin, due to their outstanding merits, have received more and more attention in the field of drug
delivery systems. In particular, maltodextrin seem to be the most promising materials in the preparation of
niosome carriers. This study aimed to optimize and characterize the formulation of natural maltodextrin-based
niosome. The natural maltodextrin was made from cilembu sweet potato starch which used partial starch
hydrolysis method by α-amylase enzyme. Proniosome and niosome formulations used three various
concentration of surfactant (sorbitan monostearat) which about 5 mmol, 7.5 mmol, and 10 mmol for formula 1
(F1), formula 2 (F2), and Formula 3 (F3) respectively. In addition, physical and chemical characterizations had
been done to characterize maltodextrin, proniosome, and niosome. The Dextrose Equivalent (DE) value of
natural maltodextrin was 7.99+0.11. Furthermore, the vesicle size of proniosome was in the range of 5μ to 13μ.
The entrapment percentages of piroxicam in niosome formulations were 72.5+1.1%,, 76+1.7 %, and 77.5+1.9 %
for FI, F2 and F3 respectively. It can be concluded that the result provided an indication of natural maltodextrin
from Cilembu sweet potato starch are potentialy carrier in the proniosome preparation which can be used for
producing niosomes.
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Keywords
Piroxicam, Niosome, Maltodextrin, Cilembu Sweet Potato Starch, α-amylase
Citation
Wathoni Nasrul, Sriwidodo, Insani Uray Camila. Characterization and Optimization of Natural Maltodextrin-based Niosome. Journal of Applied Pharmaceutical Science. 2013 July; 3(7): 68-71.