Anti-Inflammatory Potential of Ethanolic Extracts from Aerial Parts of Ipomoea Pes-Caprae (L.) R.Br Using Cotton Pellet Induced Granuloma Model.
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Date
2013-07
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Abstract
Ipomoea Pes-caprae (L.) R.Br (IP) is a valuable medicinal plant, distributed in the tropics and subtropics regions
and used in folk and tribal medicines. Traditionally IP is used in inflammatory conditions such as arthritis and
also used to treat pain, ulcer, cancer and wounds. The acute anti-inflammatory activity of IP has been previously
reported. The present study aims to discover the anti-inflammatory effect of ethanolic extracts from aerials parts
of IP by sub-acute anti-inflammatory model. Completely dried leaves and stems of I.pes-caprae were extracted
using ethanol by hot percolation method. The EELIP & EESIP (Ethanolic extract of Leaves & Stems of IP) thus
obtained were subjected to preliminary phytochemical analysis and revealed the presence of alkaloids,
carbohydrates, glycosides, flavonoids, tannins, sterols and terpenoids both in leaf and stem extracts. The LD50 of
both EELIP & EESIP were found to be >2000 mg/kg by acute oral toxicity study. Both EELIP & EESIP
exhibited significant anti-inflammatory activities in dose dependent manner.
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Keywords
Ipomoea Pes-caprae, Sub-acute inflammatory model, phytochemical analysis, acute oral toxicity study
Citation
Venkataraman N Deepak, Atlee W Clement, Prabhu T Purushoth, Kannan R. Anti-Inflammatory Potential of Ethanolic Extracts from Aerial Parts of Ipomoea Pes-Caprae (L.) R.Br Using Cotton Pellet Induced Granuloma Model. Journal of Applied Pharmaceutical Science. 2013 July; 3(7): 61-63.