In vitro antiviral activity of seeds from Guettarda angelica against avian viruses.
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Date
2013-07
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Abstract
The aim of this study was to evaluate the inhibition of the aqueous extract of seeds (AEs) from Guettarda
angelica on cell infection by two avian RNA viruses: avian reovirus (ARV) and metapneumovirus (AMPV). The
cytotoxic and antiviral activities were evaluated by MTT assay to determine the 50% cytotoxic (CC50) and
inhibitory concentrations (IC50). The selectivity index (SI=CC50/IC50) also carried out. AEs exhibited antiviral
activity only against ARV presenting IC50 of 23.59μg/mL. This inhibition was not due to any cytotoxic effect of
AEs since the CC50 on Vero cells was of 400.60μg/mL and its SI was of 17.00; this extract also showed a
virucidal effect on ARV. Previous studies also demonstrated antiviral activity of AEs extract against three animal
herpesviruses. Thus, the seeds from G. angelica showing antiviral activity against DNA and RNA viruses,
enveloped and non-enveloped, could be promising source of new antiviral agents encouraging its fractionation to
isolate the active compound.
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Keywords
Guettarda angelica, seeds, avian reovirus, antiviral activity, virucidal
Citation
Barros Alyne Vieira, Conceicao Aline Oliveira da, Simoni Isabela Cristina, Padilla Marina Aiello, Fernandes Maria Judite Bittencourt, Arns Clarice Weis. In vitro antiviral activity of seeds from Guettarda angelica against avian viruses. Journal of Applied Pharmaceutical Science. 2013 July; 3(7): 31-33.