Efficacy of pyroligneous acid from Rhizophora apiculata on pathogenic Candida albicans.
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Date
2013-07
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Abstract
Rhizophora apiculata pyroligneous acid which is a crude condensate produced from the distillation of smoke
generated in the process of charcoal making has the potential to be used as antifungal agent especially to treat
candidal infections. In this study, pyroligneous acid (PA), concentrated pyroligneous acid (CPA),
Dichloromethane extracts of CPA namely DCM A and B were tested against four pathogenic strains of Candida
albicans. The results exhibited significant inhibition zones within the range of 7.00 -8.00 mm for PA, 16.00-
17.00 mm for CPA, 16.00-18.00 mm for DCM A and 19.00-22.00 mm for DCM B. The results also revealed that
extract DCM B of CPA was the most potential to be used as anticandidal agent with the minimum inhibitory
concentration values between 3.13-6.25 mg/mL. Scanning electron micrographs of DCM B treated C. albicans
cells confirmed the damaged cells caused by the extract.
Description
Keywords
Rhizophora apiculata, Candida albicans, pyroligneous acid, candidiasis
Citation
Ibrahim Darah, Kassim Jain, Sheh-Hong Lim, Rusli Wendy. Efficacy of pyroligneous acid from Rhizophora apiculata on pathogenic Candida albicans. Journal of Applied Pharmaceutical Science. 2013 July; 3(7): 7-13.