Preparation, Characterization and In-vitro Evaluation of Microcapsules for Controlled Release of Diltiazem Hydrochloride by Ionotropic Gelation Technique.
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Date
2013-04
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Abstract
The problems of frequent administration and variable low bioavailability after oral administration of
conventional dosage forms of diltiazem can be attenuated by designing it in the form of microcapsules which
would facilitate intimate contact with the absorption surface and thereby improve and enhance the
bioavailability. Diltiazem-loaded microcapsules were successfully prepared by ionotropic gelation technique
employing Sodium carboxy methylcellulose, Xanthan gum as rate controlling polymers and Aluminium
chloride as cross linking agent. Microcapsules obtained were discrete, spherical, free flowing and showed a
maximum encapsulation efficiency of 91.20 ± 0.08%. Particle size of the microcapsules was found to be in
the range of 1009 – 1311 μm. Interaction studies performed using FTIR spectroscopy revealed that there were
no drug and polymer interactions. The drug remained dispersed in the polymer matrix in amorphous state,
which was confirmed by X-ray diffraction analysis. The in vitro drug release follows matrix-diffusion
controlled release and the release mechanism was non-Fickian type controlled by swelling and relaxation of
polymer. There was no significant change in drug content and cumulative drug release of drug-loaded
microcapsules stored at different storage condition after 90 days. From the study, it was concluded that
diltiazem loaded microcapsules could be successfully prepared by ionotropic gelation technique with high
entrapment efficiency and prolonged release characteristics.
Description
Keywords
Diltiazem hydrochloride, Ionotropic gelation technique, Sodium carboxymethyl cellulose, Xanthan gum, non-Fickian release
Citation
Akifuddin S K, Abbas Z, Marihal Sachin, Ranadev A K, Kumar I H Santosh, Kulkarni R. Preparation, Characterization and In-vitro Evaluation of Microcapsules for Controlled Release of Diltiazem Hydrochloride by Ionotropic Gelation Technique. Journal of Applied Pharmaceutical Science. 2013 Apr; 3(4): 35-42.