Synthesis and antihypertensive activity of some quinazoline derivatives.
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Date
2013-03
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Abstract
Quinazoline derivatives have been very well known for Antihypertensive activity. Seven new Quinazoline
derivatives are synthesized by three steps. Purity of compound is checked by TLC monitoring. All
synthesized compounds are confirmed by UV, IR, Mass and H1NMR. All synthesized compound were
screened for α1-adrenergic receptor blocking activity. Amongst all synthesized compounds 4a & 4e showed
better activity.
Description
Keywords
Quinazolin-4-(3H)-one, α1-adrenergic receptors blocking activity, Mass spectra, Nuclear Magnetic Resonance spectra
Citation
Patel Harsha U, Patel Ravi S, Patel Chhaganbhai N. Synthesis and antihypertensive activity of some quinazoline derivatives. Journal of Applied Pharmaceutical Science. 2013 Mar; 3(3): 171-174.