Antioxidant interactions of Pefloxacin, garlic, vitamins C and E on lipid profile level of Albino wistar rats.
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Date
2013-03
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Abstract
The lipid profile studies of garlic, antioxidant vitamins C and E on pefloxacin-induced toxicity in wistar rat was
evaluated. Method: One hundred adult wistar rats (120-180), of either sex were randomly selected into five study
groups. Each group comprised of 10 pairs (ten males and ten females) were not allowed to mate, with group 1 as
control. Group 11 were pefloxacin treated only while group 111 to 1V were pefloxacin treated with either garlic,
vitamins C and E. Pefloxacin, garlic vitamin C and E in doses 11.43mg/kg, 4.28mg/kg, 14.29mg/kg body weight
in normal saline (vehicle) was administered orally by intubation to male and female of groups 11 to V for 14
days. Control animals received 0.5ml of normal saline. In life observation measurements were taken and at the
end of drug, garlic, antioxidant vitamins C and E combined administration animals were sacrificed and tissues
obtained for biochemical assessment. Result: Physical signs of toxicity and ameliorating effects of antioxidant
vitamins and garlic were also expressed in rats, pefloxacin treatment induced significant (P<0.05) increase in
total cholesterol, low density lipoprotein, very low density lipoprotein, triacylglycerol and decrease in high
density lipoprotein relative to control but PF exposed and antioxidant vitamins C, E and garlic treated groups
produced significant (P<O.O5) reduction in TC, LDL, VLDL, TG and with an increase in HDL levels relative to
PF only treated groups were observed. Conclusion: These results suggest adverse effect of pefloxacin and
ameliorating role of garlic, vitamins C and E on wistar rats’.
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Keywords
Pefloxacin, garlic, vitamins C and E, total cholesterol, low density lipoprotein, very low density lipoproteinl, triacylglycerol and high density lipoprotein
Citation
Ukpanukpong R U, Eteng M U, Dasofunjo K. Antioxidant interactions of Pefloxacin, garlic, vitamins C and E on lipid profile level of Albino wistar rats. Journal of Applied Pharmaceutical Science. 2013 Mar; 3(3): 167-170.