Immunological profile in neonatal hyperbilirubinemia.

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1989-08-01
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Thirty cases of neonatal hyperbilirubinemia of varying etiology, severity and duration; and twenty six normal healthy newborns were subjected to various tests of cellular and humoral immunity. The results revealed a significant depression of all the parameters of cellular immunity in neonatal hyperbilirubinemia of greater than or equal to 10 mg/dl as compared to the control values. The depression of immunological profile in these newborns was seen to be more pronounced with increasing duration and severity of jaundice. A limited assessment of the humoral immunity by the B cell count and serum immunoglobulin IgG levels, however, showed no significant difference from the control.
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Sethi RK, Mishra PK, Sethi A, Saxena KP, Kumar R. Immunological profile in neonatal hyperbilirubinemia. Indian Pediatrics. 1989 Aug; 26(8): 787-92