Preliminary Anticancer Potency Evaluation and Phytochemical investigation of Methanol Extract of Piper claussenianum (Miq.) C. DC.
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Date
2013-02
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Abstract
Bioassay guided isolation of active natural compounds was performed to investigate the anti-tumor potential of
the crude extract and isolated compounds from inflorescences of Piper claussenianum. LC-DAD-UV, GC-MS
and NMR analyzes revealed the presence of phenolic metabolites in the methanol crude extract. Phytochemical
procedures lead to the isolation of the major flavonoids, 2’,6’-dihydroxy-4-methoxychalcone, 5,7-
dihydroxyflavanone and 5-methoxy-7-hydroxyflavanone that were assayed for inhibition or viability stimulation
of the human breast cancer cell line MCF-7. The results suggest the 2’,6’-dihydroxy-4-methoxychalcone as the
biologically active compound in the crude methanol extract of inflorescences from P. claussenianum. The crude
extract was found as potential natural source of compounds with breast cancer cell inhibition properties. All
isolated compounds have not been described from this species yet.
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Keywords
Piperaceae, Piper claussenianum, Anti-tumoral activity, flavonoid, chalcone, natural products
Citation
Marques Andre M, Paiva Renan A de, Fonseca Leonardo M da, Capella Marcia A M, Guimaraes Elsie F, Kaplan Maria Auxiliadora C. Preliminary Anticancer Potency Evaluation and Phytochemical investigation of Methanol Extract of Piper claussenianum (Miq.) C. DC. Journal of Applied Pharmaceutical Science. 2013 Feb; 3(2): 13-18.