Formulation and evaluation of colon targeted drug delivery system of levetiracetam using pectin as polymeric carrier.
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Date
2013-01
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Abstract
The aim of the present work was to develop and evaluate colon specific sustained release tablet using
levetiracetam (LEV), microbially degradable polymeric carrier (pectin), coating material and matrix forming
polymers. The colon targeted tablet was prepared by wet granulation technique using different percentage of
pectin as matrix carrier, starch mucilage as a binding agent, HPMC K-100 as swellable polymer and coated with
Eudragit polymers. Pectin, drug and physical mixture were evaluated for incompatibility study by Fourier
transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). All the batches of matrix
tablet (F1-F4) were subjected for in-vitro dissolution in various simulated gastric fluids for suitability for colon
specific drug delivery system. Tablets were evaluated for micromeritic properties of granules, physical
properties, drug content, water uptake and erosion characteristics. F2 was optimized and subjected to coating
based on evaluation results. The dissolution study of F2 revealed, in simulated intestinal fluid (SIF) release was
40.48% at the end of 6h and in simulated colonic fluids (rat caecal content) was 102.88% after degradation at the
end of 8h. The colon targeted matrix tablet of LEV showed no change either in physical appearance, drug content
or dissolution pattern after performing stability study for 3 months. The studies confirmed that, the designed
formulation could be used potentially for colon delivery by controlling drug release in stomach and the small
intestine.
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Keywords
Levetiracetam, Pectin, colon targeted matrix tablet, Eudragit polymer, rat caecal content
Citation
Amish Ashvinkumar Dangi, Ganure Ashok L, Jain Divya. Formulation and evaluation of colon targeted drug delivery system of levetiracetam using pectin as polymeric carrier. Journal of Applied Pharmaceutical Science. 2013 Jan; 3(1): 78-87.