Evaluation of anti-diarrheal and anti-diabetic activities of the stem, barks and leaves of the plant Vernonia cinerea (Family: Asteraceae).
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Date
2013-01
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Abstract
The aim of this study was to evaluate the anti-diarrheal, anti-diabetic activity of barks and leaves of the plant
V. cinerea. The acute toxicity test was also carried out on the stems, barks and the leaves of the plant
V.Cineria was sun dried and extracted using methanol. Later the crude methanolic extract was fractionated
into three different fractions using carbon-tetrachloride, di-chloromethane and water. The anti-diarrheal
activity was tested using the non polar carbon-tetra-chloride fraction in a dose dependent manner and it was
found that the fraction does not possess any anti-diarrheal activity. The anti-diabetic study was done in rats
using the alloxan-induced diabetes method. The carbon tetrachloride fraction of methanolic stem-bark and
leaves extract of V. cinerea in all the doses used caused a time dependent and significant (p < 0.05) reduction
of the blood glucose levels of the alloxan-induced diabetic rats when compared to the negative control group.
The highest activity of V. cinerea extract in this experiment was observed at the dose of 500 mg/kg. Acute
toxicity was done by following the method of Lorke. The acute toxicity in rats produced no death or signs of
toxicity even at the highest dose of the extract (3500 mg/kg).
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Keywords
Anti-diarrheal activity, castor oil, anti-diabetic activity, alloxan monohydrate, Acute toxicity
Citation
Haque Md Ahsanul, Abdullah Chowdhury Sayef, Romana Bilquis, Rafique Md Bodruddoza, Zia-ul-Huda Gazi Md, Hossain Sarder Fahim, Begum Bilkis. Evaluation of anti-diarrheal and anti-diabetic activities of the stem, barks and leaves of the plant Vernonia cinerea (Family: Asteraceae). Journal of Applied Pharmaceutical Science. 2013 Jan; 3(1): 69-72.