Evaluation of physical and chemical stability of nanostructured lipid carries containing ursolic acid in cosmetic formulation.
Loading...
Date
2013-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The new generation of lipid nanoparticles with solid matrix are the NLC (Nanostructured lipid carriers), and
these nanoparticles show increased chemical stability of drug, film formation, controlled occlusion, increased
skin hydration, the bioavailability of the active skin is improved, increase the physical stability of lipid
nanoparticles in topical formulations and lower toxicity. The NLC were produced by the technique of High
Pressure Homogenization (HPH). The Accelerated Stability Test, also known as Normal Stability or exploratory,
aims to provide data to predict product stability, shelf life and formulation compatibility with the packaging
material. Therefore, this study aims: to evaluate the normal stability under varying conditions of temperature and
luminosity over time as their physical and chemical characteristics in cosmetic formulation containing ursolic
acid in free and nanoparticle forms. Based on the results, the ursolic acid in the nanostructured lipid carrier form
achieved a better physical and chemical stability compared to ursolic acid in the free form in both variation of the
viscosity and pH.
Description
Keywords
ursolic acid, stability, Nanostructured lipid carriers, cosmetic formulation
Citation
Mandelli Almeida Mariana, Nadia A Bou-Chacra, Denise Conte Juliana, Mary Kaneko Telma, Rolim Baby Andre, Robles Velasco Maria Valeria. Evaluation of physical and chemical stability of nanostructured lipid carries containing ursolic acid in cosmetic formulation. Journal of Applied Pharmaceutical Science. 2013 Jan; 3(1): 5-8.