Hepatoprotective and Antioxidant Activity of Ethanol Extract of Cynoglossum zeylanicum (Vahl ex Hornem) Thurnb ex Lehm in CCl4 Treated Rats.
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Date
2012-12
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Abstract
This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of
whole plant of Cynoglossum zeylanicum on CCl4 induced hepatotoxicity in rats. Activities of liver marker
enzymes, SGOT, SGPT and ALP, total protein, albumin, globulin, total, conjugated and unconjugated
bilirubins at an oral dose of ethanol extract of Cynoglossum zeylanicum(50, 100 and150mg/kg) showed a
significant hepatoprotective effect. Regarding antioxidant activity, ethanol extract of Cynoglossum
zeylanicum exhibited a significant effect showing increasing levels of SOD, CAT, GPx, GSH and GRD
by reducing malondialdehyde (MDA) levels.
Description
Keywords
Hepatoprotective activity, Antioxidant, CCl4, Bilirubin, MDA, GGT
Citation
Anitha M, Daffodil E D, Muthukumarasamy S, Mohan V R. Hepatoprotective and Antioxidant Activity of Ethanol Extract of Cynoglossum zeylanicum (Vahl ex Hornem) Thurnb ex Lehm in CCl4 Treated Rats. Journal of Applied Pharmaceutical Science. 2012 Dec; 2(12): 99-103.