What Are The Effects of Silibinin on Testicular Tissue of Mice.
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Date
2012-11
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Abstract
Silibinin (silybin) is one of the structural isomers of the flavonoid silymarin, and it has wide variety of
phytotherapeutic applications and the aim of this study was to investigate the effects of different doses of
silibinin on testicular tissue of mice. Twenty male Swiss albino mice were divided into four groups. Each
group consist of five animal, (Group 1) (negative control) animals were administered single intraperitoneal
(IP) daily dose of phosphate buffer for 5 days, Groups ( 2, 3, and 4) were given a single IP daily dose of
either (50, 100 or 150 mg/kg B.wt.) of silibinin respectively for 5 days. Microscopic examinations of
sperms, histological examinations of testes and serum testosterone level had been measured. It was found
that silibinin in doses of (100 or 150) mg/Kg produced a significant increase (P<0.05) in the level of
testosterone in comparison with group 1. Also, silibinin in dose of 100 mg/Kg showed a significant
increase in the diameter of spermatide, and significant increase was observed in group of animals treated
with 150 mg/kg of silibinin concerning the diameter of primary spermatocyte and diameter of spermatide.
The results indicate that silibinin can improve some testicular parameters as well as testosterone levels.
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Keywords
Silibinin, Silymarin, Testosterone, Leydig cell, Testicular tissue
Citation
Oufi Hayder G, Al-Shawi Nada N, Hussain Saad A R. What Are The Effects of Silibinin on Testicular Tissue of Mice. Journal of Applied Pharmaceutical Science. 2012 Nov; 2(11): 9-13.