Effect of Recrystallization on the Pharmaceutical Properties of Valsartan for Improved Therapeutic Efficacy.
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Date
2012-10
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Abstract
Valsartan (VAL) is a potent, highly selective and orally active antihypertensive drug and is poorly soluble in
aqueous fluids, especially in gastric fluids, and its absorption is thus dissolution rate limited. In the present
research work an attempt has been made to improve the aqueous solubility of VAL by the recrystallization of
VAL from a variety of different organic solvents, and evaluating the recrystallized VAL products for its
physicochemical characteristics and in-vitro dissolution properties. The water solubility of methanol (MET),
ethanol (ETH), isopropanol (ISP) and acetonitrile (AN) recrystallized products of VAL is significantly
higher when compared to untreated VAL. Physicochemical characterization techniques like scanning
electron microscopy, differential scanning calorimetry, powder X-RD reveal the change in crystallinity of
VAL with recrystallized products and hence the increase in the solubility and superior dissolution properties
when compared to the untreated VAL.
Description
Keywords
Valsartan, recrystallization, physicochemcial characterization, dissolution studies
Citation
Nalluri Buchi N, Krishna M Ramya, Rao T P, Crooks Peter A. Effect of Recrystallization on the Pharmaceutical Properties of Valsartan for Improved Therapeutic Efficacy. Journal of Applied Pharmaceutical Science. 2012 Oct; 2(10): 126-132.