In-vivo antioxidant activity of Premna corymbosa (Rottl.) against streptozotocin induced oxidative stress in Wistar albino rats.
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Date
2012-10
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Abstract
The aim of the study was to investigate the invivo antioxidant activity of ethanolic extract Premna corymbosa
(Rottl.) root against streptozotocin induced oxidative stress in different organs (liver, kidney, brain, heart and
pancreas) of rats. Ethanolic extract of P.corymbosa (Rottl.) root was administered orally (200 mg/kg body
weight) and the effect of extract on enzymatic antioxidants like superoxide dismutase (SOD), catalase (CAT),
glutathione peroxidase (GPx), glutathione-S-transferase (GST) and polyphenol oxidase (PPO), non
enzymatic like vitamin C, vitamin E and glutathione. Lipid peroxidation like basal, ascorbate and peroxide
induced lipid peroxidation were also estimated. Glibenclamide was used as standard reference drug. A
significant increase in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-Stransferase
and reduced glutathione were observed in different organs of diabetic rats on treatment with 200
mg/kg body weight of P.corymbosa (Rottl.) root extract and glibenclamide for 30 days treatment. Both the
treated groups showed significant decrease in lipid peroxidation, suggesting its role in protection against lipid
peroxidation induced membrane damage. P.corymbosa (Rottl.) possesses antioxidant potential which may be
used for therapeutic purposes mainly in the prevention of oxidative damage that occur during diabetes.
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Keywords
P.corymbosa (Rottl.), oxidative, stress, antioxidants, streptozotocin and vital organs
Citation
Shilpa Varikkasseri Neelakandhan, Rajasekaran Narmadha, Gopalakrishnan Velliyur Kanniappan, Devaki Kanakasabapathi. In-vivo antioxidant activity of Premna corymbosa (Rottl.) against streptozotocin induced oxidative stress in Wistar albino rats. Journal of Applied Pharmaceutical Science. 2012 Oct; 2(10): 60-65.