Effects of Rosiglitazone and Acarbose (with and without Cornstarch Diet) on Serum Electrolytes in Diabetic Rats.
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Date
2012-09
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Abstract
The purpose of this study is to highlight potential risks associated with the use of oral hypoglycemics as
monotherapy in treatment of type 2 diabetes mellitus. For this study 40 Wistar albino rats were equally
divided into four groups. Group I served as diabetic control and II, III and IV were treated with acarbose
with regular diet, acarbose with cooked cornstarch diet and rosiglitazone respectively. Diabetes was induced
with a single dose of alloxan monohydrate IP at a dose of 150 mg/kg body weight. Drug samples were
administered orally for a period of 4 weeks and effects of the drugs were studied on day 7, 15 and 30 for
serum level of sodium and potassium. Results showed decrease in sodium and potassium level in all treated
groups on day 7. On day 30 levels were increased in group II and IV but decreased significantly in group III.
It has been concluded that chronic doses of rosiglitazone and acarbose with regular diet may cause abnormal
levels of electrolytes which may cause irregular cardiac contractility. Administration of acarbose with
cornstarch diet may be beneficial in regulating cardiac contractility.
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Keywords
Resistant starch, oral hypoglycemic, cardiac toxicity, serum electrolytes, nephrotoxicity, alphaglucosidase inhibitor
Citation
Khatoon Humera, Najam Rahila. Effects of Rosiglitazone and Acarbose (with and without Cornstarch Diet) on Serum Electrolytes in Diabetic Rats. Journal of Applied Pharmaceutical Science. 2012 Sept; 2(9): 50-53.