Antispasmodic Effects of Aqueous extract of Anthemis mauritiana Maire & Sennen Flowers.
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Date
2012-09
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Abstract
The effects of aqueous extract of Anthemis mauritiana Maire & Sennen flowers (AM) on rabbit and rat
jejunum were studied. The AM (0.1-3 mg/mL) showed reversibly relaxation of spontaneous contractions on
isolated rabbit jejunal smooth muscle The spasmolytic effect was dose-dependent with IC50 value of 1,48 ±
0,02 mg/ml. Similarly this extract inhibited the contractions of rat jejunum induced by KCl (75mM) and
Carbachol (CCh, 10-6M) with IC50 values of 0,48 ± 0,09 mg/ml and 1,53 ± 0,03 mg/ml respectively.
Furthermore, AM exhibited an inhibitory effect on the dose-response curves induced by CCh and CaCl2 on rat
jejunum. These results clearly demonstrated the antispasmodic effect of AM which was strongly suggested to
be mainly due to the inhibitory effect on Ca++ influx through membrane of jejunal smooth muscle.
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Keywords
Anthemis mauritiana Maire & Sennen, jejunum, rodent, antispasmodic
Citation
Aziz Mohammed, Karim Ahmed, Mekhfi Hassane, Bnouham Mohamed, Ziyyat Abderrahim, Legssyer Abdelkhaleq, Melhaoui Ahmed. Antispasmodic Effects of Aqueous extract of Anthemis mauritiana Maire & Sennen Flowers. Journal of Applied Pharmaceutical Science. 2012 Sept; 2(9): 41-44.