Acute and subacute oral toxicity evaluation of benincasa hispida extract in rodents.
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Date
2012-08
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Abstract
The toxicity studies were carried out a 50% aqueous ethanolic extract of Benincasa
hispida ( B. hispida )in rodents.The acute toxicity study, B. hispida was found to be well tolerated
upto 2000mg/kg, produced neither mortality nor in behavior in mice. In subacute toxicity study, B.
hispida at dose level of 200 and 400 mg/kg did not produce any significant difference in their
body weight, food and water intake when compared to vehicle treated rats. It also showed no
significant alteration in hematological and biochemical parameters in experimental groups of rats
apart from a decrease in aspatate transaminase, alanine transaminase and alkaline phosphate
content at the dose of 400 mg/kg. Histopathological study revealed normal architecture of kidney
and liver of B. hispida treated rats. These results demonstrated that there is a wide margin of
safety for the therapeutic use of B. hispida and further corroborated the traditional use of this
extract as an anti hepatocarcinogenic agent.
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Benincasa hispida: Acute and sub acute toxicity
Citation
Patel R K, Patel S B, Shah J G. Acute and subacute oral toxicity evaluation of benincasa hispida extract in rodents. Journal of Applied Pharmaceutical Science. 2012 Aug; 2(8): 250-253.