Development and Validation of Analytical Method for Quantitative Estimation of Miglitol and Metformin in Combined Dosage Form.
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Date
2012-07
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Abstract
A simple, accurate, economical and reproducible UV spectrophotometric method for
simultaneous estimation of Miglitol and Metformin in combined tablet dosage form has been
developed. The developed method employs multi component spectroscopy using 300nm, 270nm,
240nm and 210nm as wavelengths for estimation. Miglitol and Metformin were found to be linear
in the concentration range of 0.2-1.2 μg/ml and 2-12 μg/ml respectively. %Assay was found to be
in the range of 99.27 – 99.92% and 99.29 – 99.97% for Miglitol and Metformin respectively.
Results of analysis were validated statistically in accordance with ICH guidelines.
Description
Keywords
Miglitol, Metformin, Multi Component Spectroscopy
Citation
Patel Sejal R, Kabra Prachi V, Kimbahune Ritu V, Markad Ravikiran, Nargund L V G. Development and Validation of Analytical Method for Quantitative Estimation of Miglitol and Metformin in Combined Dosage Form. Journal of Applied Pharmaceutical Science. 2012 July; 2(7): 227-229.