The Pharmacokinetic and Biopharmaceutical Effect of Ascorbic acid (Vitamin C) on Pefloxacinon Concurrent Administration in Human.
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Date
2012-07
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Abstract
The aim of the study was to assess the pharmacokinetic and biopharmaceutical effect
of ascorbic acid (Vitamin C) on pefloxacin on concurrent administration in man through urine
excretion data and microbiological evaluation. A two way crossover study was performed in
ten healthy male volunteers aged (Mean ± SD) 45 ± 5.5 years and weight (Mean ± SD) 75.4 ±
12.5 Kg recruited and given pefloxacin 400mg as single dose and urine samples collected and
pooled up at time intervals. The drug was concurrently given with 500mg vitamin C after a
washout period of 4 weeks and urine samples similarly collected. Urine samples collected were
analyzed and pefloxacin concentrations were determined with UV spectrophotometer from a
validated calibration curve. The pharmacokinetic parameters Cmax, tmax, Ke and t1/2 were
determined and compared. Microbial evaluation of the interaction of the drugs was performed
through MIC determination using urinary isolate S. aureus (U-11420). The ke for pefloxacin
alone was significantly lower than that for pefloxacin concurrently administered with vitamin
C (0.1hr-1 and 0.3hr-1) P<0.05. The amount of pefloxacin excreted was significantly lower on
single administration of pefloxacin compared to the co-administration with vitamin C,
(44.13mg against 141.99mg) at P<0.05. The MIC obtained against S. aureus was 0.025mg/ml
for pefloxacin alone while the co-solution with vitamin C at below 2hr and 4hr impregnation
period was 0.05mg/ml and 0.1mg/ml respectively. There was significant chemical,
microbiological and biopharmaceutical interaction on co-administration of pefloxacin with
vitamin C.
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Keywords
Pefloxacin, vitamin C, Co-administration, Biopharmaceutical interaction
Citation
Awofisayo S O, Umoren F J, Uwanta E J. The Pharmacokinetic and Biopharmaceutical Effect of Ascorbic acid (Vitamin C) on Pefloxacinon Concurrent Administration in Human. Journal of Applied Pharmaceutical Science. 2012 July; 2(7): 107-110.