In-vivo and in-vitro screening of medicinal plants for their anti-inflammatory activity: an overview.
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Date
2012-07
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Abstract
Despite the progress made in medical research for the past decades, the treatment of
many serious diseases is still problematic. Inflammation is the response of living tissues to
injury. It involves a complex array of enzyme activation, mediator release, extravasations of
fluid, cell migration, tissue breakdown and repair. Inflammation has become the focus of global
scientific research because of its implication in virtually all human and animal diseases. As a
result of adverse effects such as gastric lesions caused by non-steroidal anti-inflammatory drugs
(NSAID), tolerance and dependence induced by opiates, the use of these drugs as antiinflammatory
agents have not been successful in all cases. Therefore, new anti-inflammatory
drugs lacking these side effects are being researched as alternatives to NSAID and opiates.
Attention is being focused on the investigation of the efficacy of plant-based drugs used in the
traditional medicine because they are cheap, have little side effects. Hence, in the present review
the various animal models used for preclinical screening anti-inflammatory activity herbs was
compiled.
Description
Keywords
Inflammation, Animal Models, Plant Extract, Mechanism of action
Citation
Phanse Mohini A, Patil Manohar J, Abbulu Konde, Chaudhari Pravin D, Patel Bhoomi. In-vivo and in-vitro screening of medicinal plants for their anti-inflammatory activity: an overview. Journal of Applied Pharmaceutical Science. 2012 July; 2(7): 19-33.