Multiparticulate formulation of Valdecoxib for the treatment of rheumatoid arthritis.
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Date
2012-06
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Abstract
An oral controlled onset dosage form intended to approximate the chronobiology of
rheumatoid arthritis was proposed for colonic targeting. The multiparticulate system
comprising of non-pareil seeds coated with Eudragit S100 was designed for chronotherapeutic
delivery of valdecoxib. The drug was coated onto non-pareil seeds by powder layering
technique using the conventional coating pan. Different coat weights of non-aqueous
dispersions were applied onto the drug-coated pellets using spray coating technique. In vitro
dissolution tests of the coated pellets were performed in different pH media for a period of 11
hours. The in-vitro dissolution tests showed that the release of valdecoxib from the coated
pellets depended on the pH of the dissolution fluid and the coat weights applied. All the
formulations exhibited no release of drug in the pH 1.2 and pH 4 buffers; drug release took
place in phosphate buffer of pH 7.4. Further intactness of the drug in the formulation and the
uniformity of the polymer coating were checked by the infrared study and scanning electron
microscopy. Stability studies inferred that the drug undergoes no considerable degradation
pattern at room temperature and 40oC even after three weeks. All the above results show that
the formulation could be highly advantageous in the chronotherapy of rheumatoid arthritis with
appreciable drug release and physiochemical properties.
Description
Keywords
Oral controlled onset dosage form, Chronobiology, Eudragit S100, Valdecoxib, Powder layering technique, multiparticulate system
Citation
Rupesh Audity Ganguly, Suresh Sarasija, Pandit Vinay. Multiparticulate formulation of Valdecoxib for the treatment of rheumatoid arthritis. Journal of Applied Pharmaceutical Science. 2012 June; 2(6): 217-222.