Formulation and Evaluation of Bi-layered Sustained Release Matrix Tablets of Tramadol Hydrochloride.
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Date
2012-06
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Abstract
Bi-layer tablets of tramadol hydrochloride were prepared by direct compression
technique incorporating an immediate release layer and a sustained release layer. An immediate
release layer was successfully designed to release the bolus dose instantaneously. Water soluble
Xanthan gum, water insoluble Kollidon SR and Eudragit L 100 were used as carriers in the
sustained release layer of the matrix tablet. All the tablets were evaluated for thickness, diameter,
weight variation, hardness and friability. The in vitro drug release was studied for eight hour,
first two hours dissolution in acidic medium followed by six hour dissolution in buffer medium.
Matrix tablet showed a sustained release rate with a controlled fashion as a function of the
quantity of polymer used. The in vitro drug release data were fitted with several mathematical
models and mean dissolution time along with fractional dissolution time values (T25%, T50% and
T80%) were calculated. Xanthan gum was found to be the most effective rate retarding agent
compared to Kollidon SR and Eudragit L 100, when used at same ratio in the formulations.
Description
Keywords
Bi-layer tablet, Matrix tablet, immediate release layer, sustained release layer, release exponents and MDT
Citation
Rahman Sharmin, Masum Md Abdullah Al, Sharmin Florida, Islam S M Ashraful, Reza Md Selim. Formulation and Evaluation of Bi-layered Sustained Release Matrix Tablets of Tramadol Hydrochloride. Journal of Applied Pharmaceutical Science. 2012 June; 2(6): 129-134.