Proliferative Effect of Aqueous Extracts ofParquetina Nigrescens on HaemopoieticMultipotent Stem Cells in Irradiated Guinea Pigs.
Loading...
Date
2012-06
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Patients suffer a decrease in haemopoietic stem cells as a consequence of disease,
radiation or chemotherapy. Radiotherapy and chemotherapy are common therapeutic modalities
for cancer, leukemia, and lymphoma. Unfortunately, these therapies are not tumor-specific.
Normal tissues, particularly the bone marrow (BM), are extremely vulnerable to cytotoxicity
caused by these therapies. Antidotes are required for the untoward side effects of these
therapies. Although a lot of potential better treatments are currently being developed, few
research studies have investigated the proliferative effect of plant extracts which may modulate
stem cells self-renewal and differentiation. However, in recent years there has been an upsurge
of interest on the effects of various dietary insufficiencies on haemopoietic and immune
responses (Sanberg et al., 2006). Other investigators have recently reported that dietary fatty
acids, particularly oleic acid and linoleic acid, actively promote the proliferation of
haemopoietic stem cells (Sanberg et al., 2006) as well as modulate the self-renewal of intestinal
epithelial cells. This study was done to determine the potential proliferative effect of
Parquetina nigrescens on haemopoietic multipotent stem cells in irradiated guinea pigs bone
marrow. The study shows that the plant has positive proliferative effects on haemopoietic
multipotent stem cells. The proliferative effect correlates with the concentration of the P.
nigrescens.
Description
Keywords
Proliferative effect, Parquetina nigrescens, Haemopoietic, Multipotent Stem Cells, Irradiated Guinea Pigs
Citation
Olatunbosun LO, Caxton-Martin A, Jimoh O R, Biliaminu S A, Ghazal O K. Proliferative Effect of Aqueous Extracts ofParquetina Nigrescens on HaemopoieticMultipotent Stem Cells in Irradiated Guinea Pigs. Journal of Applied Pharmaceutical Science. 2012 June; 2(6): 108-111.