Prolonged-release solid dispersions of ibuprofen.
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Date
2012-06
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Abstract
Ibuprofen (IB) is one of the most important non-steroidal anti-inflammatory drugs used
in the treatment of inflammatory chronic diseases. This drug presents, in the pure state, poor
physical and mechanical characteristics and their use in solid dosage forms needs the addition of
excipients which improve these properties. The selection of the best excipients and the suitable
pharmaceutical dosage form to carry ibuprofen are very important for the industrial success of
this drug. Thus, in this work, solid dispersions of ibuprofen in cethyl alcohol (SD CA), stearic
acid (SD SA) and hydrogenated castor oil (SD HCO) were prepared in order to improve physical
and mechanical characteristics of this drug. Physical mixtures with the same composition of
solid dispersions were also prepared. Solid dispersions of ibuprofen with stearic acid and
hydrogenated castor oil showed better flow characteristics than pure ibuprofen and the respective
physical mixtures. Gelatin capsules filled with solid dispersions were submitted to dissolution
tests in order to study the influence of the prepared systems in the release profiles of ibuprofen.
Prolonged-release of ibuprofen was achieved with the solid dispersions prepared with the
different types of excipients.
Description
Keywords
Ibuprofen, Solid dispersions, Physical mixtures, Hydrogenated castor oil, Stearic acid, Cethyl alcohol
Citation
Almeida Hugo, Amaral Maria Helena, Lobao Paulo. Prolonged-release solid dispersions of ibuprofen. Journal of Applied Pharmaceutical Science. 2012 June; 2(6): 67-70.