Studies on directly compressed ondansetron hydrochloride mucoadhesive buccal tablets using gelatin, chitosan and xanthan gum along with HPMC K4M.
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Date
2012-05
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Abstract
Mucoadhesive buccal tablets containing ondansetron hydrochloride (ODH)
were prepared using polymers like gelatin, chitosan, xanthan gum in varying concentration of 5,
10, 15% w/w and HPMC K4M 40% w/w by direct compression technique. Precompressional
studies revealed good micromeritic properties of powder blend for compression and were found
as per literature limits. The prepared tablets were evaluated for thickness, hardness, uniformity
of weight, drug content, friability, swelling index, mucoadhesion strength, in vitro
disintegration, dissolution time and permeation studies. The formulations containing xanthan
gum gave better mucoadhesion, release characteristics compared to those containing gelatin and
chitosan and the rank order of mucoadhesion and permeation across sheep buccal mucosa was
xanthan gum > chitosan> gelatin. The tablets apart from fulfilling all the official specifications,
exhibited higher rate of release, in vitro release from all ODH buccal tablets followed Super
case II transport due to polymer chain disentanglement and relaxation. and found to be stable
upon conducting stability studies as per ICH guidelines at 40ÂșC/75 % RH. The results revealed
that mucoadhesive buccal tablets containing ODH were successfully formulated by direct
compression technique as an alternative to conventional tablets for therapy of nausea condition
in patients.
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Keywords
Buccoadhesive tablet, Ondansetron HCl, direct compression, stability studies
Citation
Azhar Syed Amezuddin, Kumar Putta Rajesh, Sood Vivek, Shyale Somashekar. Studies on directly compressed ondansetron hydrochloride mucoadhesive buccal tablets using gelatin, chitosan and xanthan gum along with HPMC K4M. Journal of Applied Pharmaceutical Science. 2012 May; 2(5): 100-105.