Assessment of the cytotoxic effect and in vitro evaluation of the anti-enteroviral activities of plants rich in flavonoids.
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Date
2012-05
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Abstract
Nanoparticles derived from plants known for their high content of flavonoids provide
a biologically inspired route to designing therapeutic agents and a means of reducing
nanoparticle toxicity. Little is currently known on the antiviral activity of Salvia officinalis L.
and Washingtonia filifera H.Wendl aqueous extracts and their corresponding nanoparticles. In
the present study, antiviral activity of subset extracts obtained from aerial parts of Salvia
officinalis L. and Washingtonia filifera H.Wendl and nanoparticles derived from these plants
were investigated against coxsackievirus B3 (CVB3). Different concentrations of extracts (7.8,
15.6, 31.25, 62.5, 125, 250, 500, and 1000 μg/mL) were tested for their cytotoxic effect and the
antiviral activity was carried out using three non cytotoxic concentrations against CVB3 in
Vero cells. The cell viability was carried out using tetrazolium dye (MTT). The experiment was
carried out by incubating the extracts with either virus or cells prior to infection. The silver
nanoparticles derived from the tested plant extracts enhance antiviral activity at non cytotoxic
concentrations. The biosynthesized nanoparticles may be further characterized to better evaluate
their antiviral potential against other viral pathogens.
Description
Keywords
Antiviral activity, Enterovirus, Nanoparticles, Salvia officinalis, Washingtonia filifera
Citation
Abid Nabil Ben Salem, Rouis Zyed, Lassoued Mohamed Ali, Sfar Souad, Aouni Mahjoub. Assessment of the cytotoxic effect and in vitro evaluation of the anti-enteroviral activities of plants rich in flavonoids. Journal of Applied Pharmaceutical Science. 2012 May; 2(5): 74-78.