Studies on the effect of Salvia aegyptiaca and Trigonella foenum graecum extracts on adult male mice.
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Date
2012-05
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Abstract
Salvia aegyptiaca (Egyptian sage) and Trigonella foenum graecum
(fenugreek) have potential tannins, total flavonoids and total phenolics as examined
in vitro in the present study. In addition, the antioxidant effect of Egyptian sage
(ESE) and fenugreek (FE) extracts were evaluated in normal male adult mice. Also,
there is no evidence about the positive and/or negative effect of those extracts on
male fertility. In order to evaluate the beneficial effect of those extracts, liver and
kidney functions, lipid peroxidation, nitric oxide. In addition, non-enzymatic and
enzymatic antioxidant molecules as glutathione (GSH), catalase (CAT), superoxide
dismutase (SOD), glutathione reductase (GR) and glutathione-S-transferase (GST)
were estimated. Also, histological examination of testis was done. The results
revealed that both extract of ESE and FE have potent antioxidant activity by
reducing lipid peroxidation and nitric oxide formation in testis tissues of mice. Those
activities were extended to non-enzymatic and enzymatic antioxidant defense
components such as GSH, CAT, SOD, GR and GST. Additionally, ESE mixed to FE
caused enhancement in testis structure with improved seminiferous tubules and
spermatozoa. In conclusion, the results obtained showed that ESE and FE may
contain some biologically active components that may be active against oxidative
stress, and this may be the basis for its traditional use for environmental toxins.
Description
Keywords
Salvia aegyptiaca, Trigonella foenum graecum, Antioxidant properties, Oxidants/antioxidants status, Mice
Citation
Tohamy Amany A, Ibrahim Shaimaa R, Moneim Ahmed E Abdel. Studies on the effect of Salvia aegyptiaca and Trigonella foenum graecum extracts on adult male mice. Journal of Applied Pharmaceutical Science. 2012 May; 2(5): 36-43.