Analgesic and Anti-inflammatory Activities of Flower Extracts of Punica granatum Linn. (Punicaceae).
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Date
2012-04
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Abstract
Punica granatum has been used for centuries to confer health benefits in a number of
inflammatory diseases. Based on its usage in Ayurvedic and Unani medicine, dietary
supplements containing pomegranate extract are becoming popular for the treatment and
prevention of arthritis and other inflammatory diseases. Pet-ether, dichloromethane and
methanol fractions of flower part were chosen for pharmacological screening and analgesic and
anti-inflammatory activities in animal model. The anti-inflammatory activity was assessed
using the carrageenan-induced rat paw edema model. The analgesic effect was measured in
mice using the acetic acid-induced writhing test. In the acetic acid-induced writhing test in
mice, pet-ether, dichloromethane and methanol fractions at 200 mg/kg doses level showed
75.77% (p<0.001), 68.56% (p<0.001), 54.64% (p<0.001) inhibition of writhing, respectively. In
rat paw edema model induced by carrageenan, pet-ether, dichloromethane and methanol
fractions were found to reduce significantly (p<0.001) the formation of edema at the 100 mg/kg
dose level and showed 26.92% (p<0.001), 27.97%(p<0.001), 21.85%(p<0.001) inhibition
respectively of edema volume at the end of 4 h. Punica granatum possesses evident analgesic
and anti-inflammatory activities. The results signify the traditional uses of Punica granatum for
inflammation and pain.
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Keywords
Punica granatum, punicaceae, analgesic, anti-inflammatory, carrageenan
Citation
Sarker Mithun, Das Sreedam Chandra, Saha Sajal Kumar, Mahmud Zobaer Al, Bachar Sitesh Chandra. Analgesic and Anti-inflammatory Activities of Flower Extracts of Punica granatum Linn. (Punicaceae). Journal of Applied Pharmaceutical Science. 2012 Apr; 2(4): 133-136.