Chemical constituents of the Egyptian Plant Anabasis articulata (Forssk) Moq and its antidiabetic effects on rats with streptozotocin-induced diabetic hepatopathy.
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Date
2012-04
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Abstract
This study investigated the possible antidiabetic role and therapeutic crucial action
of the saponin fractions of the ethanolic extract of areal parts of the medicinal plant Anabasis
articulata compared to currently available antidiabetic drug gliclazide (diamicron) against
diabetic complications induced tissue injury in rats. Fractionation of hydro alcoholic extract
from the aerial parts of Anabasis articulata (Chenopodiaceae) led to the isolation of Four
known saponins: 3-O-glucopyranosyl of(stigmasterol, ß-sitosterol, sitostanol), 3-O-[ß-D- the
glucopyranosyl] oleanolic acid , 3-O-[ß-D-glucopyranosyl -28-O-ß-D - xylopyranosyl]
oleanolic acid, in addition to proceric acid. The isolated compounds were identified by means
of chemical methods and spectrometric analysis as Rf values, UV Mass, 1H NMR and
13CNMR spectroscopy. Animals were divided into 4 groups. Group1, control rats (not
received any medication). Group 2, rats injected intraperitoneally with single dose of
streptozotocin (STZ)(40 mg/kg body weight). Group 3, rats orally administered with
ethanolic extract of A. articulata (400 mg/ kg B.W.) after STZ injection. Group 4, rats orally
administered with gliclazide (10 mg/kg B.W.) after STZ injection. Oral administration of the
plant modulated the diabetic increase in blood glucose and cortisol levels revealing the
antihyperglycemic effect of this medicinal plant. It effectively increases the blood hormone
insulin concentration and α- fetoprotein. It is also significantly decrease blood tumor necrosis
factor α (TNF-α). The current plant also effectively decreased blood fructosamine to their
normal levels as well as the consequence diabetic decrease in the hemoglobin (Hb) and
albumin levels. Furthermore, ingestion of the plant effectively modulated hepatic oxidative
tissue damage. Supplementation of diabetic animals with gliclazide improved diabetic
induced alteration in most of the above studied markers. These results suggest that Anabasis
articulata has multi-beneficial actions in controlling diabetes and consequence complications
induced in pancreas and liver and may candidate as natural antidiabetic drug.
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Keywords
Diabetes, Streptozotocin, Anabasis articulata, Saponins, glycation, Gliclazide
Citation
Metwally Nadia S, Mohamed Azza M, ELSharabasy Fatma S. Chemical constituents of the Egyptian Plant Anabasis articulata (Forssk) Moq and its antidiabetic effects on rats with streptozotocin-induced diabetic hepatopathy. Journal of Applied Pharmaceutical Science. 2012 Apr; 2(4): 54-65.