Emerging Techniques and Challenges in Colon Drug Delivery Systems.
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Date
2012-03
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Abstract
Colon specific drug delivery has achieved utmost importance because the colon is an
area that is vulnerable to a number of diseases including ulcerative colitis, crohn’s disease,
irritable bowel syndrome and carcinomas. And, preservation of formulation in upper GIT to
colon is still important step. Treatment of these diseases with a colon-specific drug delivery
system provides an interesting alternative over systemic drug administration because of lower
dosing and fewer systemic side effects. Different challenges are associated with this delivery
system like long transit time, enzymatic interference, intersubject variation of microflora etc. A
variety of under clinical and commercially available approaches were designed for remediation
of colonic ailments. Different dosage forms like tablets, capsules, pellets, multiparticulates,
microspheres, liposome, nanoparticulates etc. were used for colon targeting. The present review
article mainly focused on different approaches, mainly on formulation, carrier system and/or
coating system, bioactive stability, patient compliance and evaluation of colon specific drug
delivery system.
Description
Keywords
Colon, pH, Microflora, Polymers, Approaches
Citation
Singh Gurmeet, Kumar Dinesh, Singh Mankaran, Sharma Deepak, Kaur Sukhbir. Emerging Techniques and Challenges in Colon Drug Delivery Systems. Journal of Applied Pharmaceutical Science. 2012 Mar; 2(3): 139-147.