White Bean Flour (Phaseolus vulgaris): Therapeutic and Toxicological Research in Wistar Rats.
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Date
2012-03
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Abstract
The objective was to evaluate the possible therapeutic and toxic effects resulting from
administration of white bean flour (WBF) in Wistar rats for 21 days. The assay was performed to
assess the consequences of using WBF crude, at a the concentration corresponding to the
recommended daily dose to cause weight loss and hypoglycemic effect, which is 1,000 mg of
phaseolamin/day. The administration of WBF at 1 mg/g body weight in Wistar rats with
diabetes induced by STZ in a period of 21 days, did not alter physiological parameters
(consumption of food and water, urine volume), biochemical markers (total cholesterol, HDL
cholesterol and triglycerides), liver enzymes (gamma-GT, AST and ALT), and weight of organs
(liver and pancreas) as well as fecal excretion of proteins and lipids. An increased excretion of
carbohydrate fecal confirms the results of inhibition of α-amylase. Despite the tendency to
decrease blood glucose from 20 days of treatment, there was no significant reduction during the
period evaluated in the treated group. It can be concluded that despite the decreasing tendency of
hyperglycemia and possibly aid in weight loss by decreasing absorption of carbohydrates in the
diet, high doses of WBF may have deleterious effects on the body resulting from chronic use.
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Keywords
Diabetes, phaseolamin, enzymatic inhibition, white bean flour
Citation
Pereira Luciana Lopes Silva, Pereira Chrystian Araujo, de Sousa Raimundo Vicente, Santos Custodio Donizete dos, de Moraes Clarissa Ferreira, Satiro Livia Cabral. White Bean Flour (Phaseolus vulgaris): Therapeutic and Toxicological Research in Wistar Rats. Journal of Applied Pharmaceutical Science. 2012 Mar; 2(3): 1-7.