Evaluation of Antidiarrhoeal activity of extract from leaves of Aegle marmelos.
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Date
2012-02
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Abstract
Aegle marmelos is a medium sized tree, widely distributed in Asia and Africa. The
plant is widely used in the ayurvedic system of medicine. Traditionally the plant has been used
for the treatment of various ailments such as pain, fever, inflammation, respiratory disorders,
dysentery and diarrhea. To justify its folklore, present study was undertaken to investigate the
antidiarrhoeal activity of the aqueous extract from the leaves of Aegle marmelos. Preliminary
phytochemical screening, acute toxicity study and antidiarrhoeal activity were studied on castor
induced diarrhea, Magnesium sulphate induced diarrhea, and gastric transit time at 50, 100and
200mg/kg body weight. The preliminary phytochemical screening of the extract results with the
presence of anthraquinone glycosides, catechins, fixed oils and saponins etc., LD50 >2000mg/kg.
The doses of aqueous extract of A.marmelos significantly decreased (P< 0.05) the total number
of diarrhoeal faeces. Percentage of inhibition of diarrhoeal faeces at 200mg/kg was comparable
with standard drug Loperamide. Conclusively, Aegle marmelos leaf extract has the antidiarrhoeal
activity in experimental rats.
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Keywords
Aegle marmelos, Diarrhea, Magnesium sulphate, Loperamide
Citation
Rao G Hari jagannadha, Lakshmi P. Evaluation of Antidiarrhoeal activity of extract from leaves of Aegle marmelos. Journal of Applied Pharmaceutical Science. 2012 Feb; 2(2): 75-78.