Colon Specific Drug Delivery Systems: A Review on Various Pharmaceutical Approaches.
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Date
2012-01
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Abstract
Colon specific drug delivery system has attracted considerable attention for the past few
years in order to develop drug delivery systems that are able to release drugs specifically in the
colon in a predictable and reproducible manner. The colon is a site where both local and systemic
delivery of drugs can take place. To achieve successful colon targeted drug delivery, a drug need
to be protected from degradation, release and absorption in the upper portion of the gastric
intestinal tract (GIT) and then to be ensured abrupt or controlled release in the proximal colon.
This review is aimed at understanding recent approaches for dosage forms which is targeting to
colon through pH sensitive system, microbially triggered system i.e., prodrugs and polysaccharide
based system, timed release system, osmotically controlled drug system, pressure dependent
release system.
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Keywords
Colon specific drug delivery, pH sensitive, time controlled dependent, microbially triggered, Pressure controlled, osmotically controlled system
Citation
Prasanth V V, Jayaprakash R, Mathew Sam T. Colon Specific Drug Delivery Systems: A Review on Various Pharmaceutical Approaches. Journal of Applied Pharmaceutical Science. 2012 Jan; 2(1): 163-169.