Efficacy of Thonningia Sanguinea Vahl. (Balanophoraceae) Root Extract Against Plasmodium Berghei, Plasmodium Chabaudi, Inflammation and Nociception in Mice.
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Date
2012-01
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Abstract
The effects of Thonningea sanguinea Vahl. root extracts were tested against
Plasmodium berghei and Plasmodium chabaudi, acetic acid induced abdominal
constriction and egg albumin induced paw oedema in rodents. Eighteen mice assigned
to 3 groups of 6 animals each were infected with P. berghei (NK 65 chloroquine
sensitive strain). Group I was treated with 300 mg/kg bw T. sanguinea, group II with
5mg/kg bw chloroquine phosphate (standard) and group III with 20ml/kg bw normal
saline (control). Another set of eighteen mice were also inoculated with P. chabaudi
and treated similarly. P. berghei was significantly suppressed by the extract over the
time course of the study with mice survival periods of 36, 20 and 16 days for
chloroquine, plant extract and normal saline treatments respectively. T. sanguinea
produced some initial suppression of parasites but subsequently resurgence in
parasitaemia was observed in the case of P. chabaudi infected animals. Mice survival
periods with the later were 24 days (CQ), 22 days (extract) and 10 days (normal
saline). Whole body weights significantly decreased in P. chabaudi but not P. berghei
infected mice. Packed Cell Volume significantly (p<0.05) decreased with both
models irrespective of the treatments. The extract had a minimal (10.89%) analgesic
effect and had no anti-inflammatory activity. T. sanguinea though effective only in
the P. berghei model could still be further investigated.
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Keywords
Thonningia sanguinea, Plasmodium berghei, Plasmodium chabaudi, Parasiteamia, Resurgence
Citation
Jigam Ali A, Abdulrazaq Usman T, Mahmud Halima A, Tijani Falilat O. Efficacy of Thonningia Sanguinea Vahl. (Balanophoraceae) Root Extract Against Plasmodium Berghei, Plasmodium Chabaudi, Inflammation and Nociception in Mice. Journal of Applied Pharmaceutical Science. 2012 Jan; 2(1): 47-51.