Improving Oral Bioavailability of Agaricoglycerides by Solid Lipid-Based Self-Emulsifying Drug Delivery System.
Loading...
Date
2011-12
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Agaricoglyceride A (AGA), showed strong activities against neurolysin. The objectives
of this study was to prepare solid self-emulsifying drug delivery system (sSEDDS) by spray
drying the SEDDS (liquid system) using Aerosil 200 as the inert solid carrier, and to evaluate the
enhanced bioavailability (BA) of AGA from sSEDDS. The AGA formulated in the sSEDDS was
quickly and completely dissolved within 20min, both in 0.1N HCl and phosphate buffer pH 6.8
dissolution media, whereas AGA powder was significantly less dissoluble. Meanwhile, the
sSEDDS formulation was stable for at least 90days at room temperature. the plasma levels of
AGA in the solid SEDDS group at the dose level (15mg/kg) remained detectable for up to 1.5 h
after the oral dose. After oral administration to rats, a significant increase (P<0.0001) in the Cpmax
and AUC0→24 h were observed in the sSEDDS group when compared with the AGA powder
group. Furthermore, AGA-loaded sSEDDS exerted significant antinociceptive properties and
alleviated pain insults in mice. The results suggest that the sSEDDS could be considered and
further evaluated for the oral delivery of lipophilic poorly soluble drugs for which an oral route of
administration is desirable.
Description
Keywords
Solid self-emulsifying, oral bioavailability, lipophilic drugs, antinociceptive properties, Agaricoglyceride A
Citation
Han Chun Chao, Han Linna. Improving Oral Bioavailability of Agaricoglycerides by Solid Lipid-Based Self-Emulsifying Drug Delivery System. Journal of Applied Pharmaceutical Science. 2011 Dec; 1(10): 195-199.