Hematological and biochemical studies on Parquetina nigrescens root extract in albino rats.
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Date
2011-12
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Abstract
The haematological, lipid, and antioxidant effects of Parquetina nigrescens (PN) were
investigated. 40 male wistar rats were grouped into 4 of 10 rats each. Group A: control;
administered 10ml/kg of normal saline. The other groups were administered extract viz: Group
B- 50mg/kg, Group C- 100mg/kg, Group D- 150mg/kg. After 21days, blood samples were
collected for different analysis. The results revealed decreased WBC count at 50 mg/kg
&100mg/kg doses (p<0.05), significant increase in RBC, PCV, & haemoglobin levels (p<0.05)
at 50mg/kg dose. There was also significant increase (p<0.05) in total cholesterol (TC), LDL
with no change in high density lipoprotein (HDL) at 100mg/kg dose while there was significant
increase in the mean TC, TG, LDL as well as HDL at 150mg/kg doses. There was also
significant increase (p<0.05) in the level of SOD activity at 100mg/kg dose and a significant
reduction in the GPx activity (p <0.05) at 50mg/kg & 100mg/kg dose groups. The observations
from this study reveal that PN possesses erythropoietic potentials at minimal dose which lends
support to its folkric use in the treatment of anaemia. It could also serve as a free radical
scavenger as it possesses antioxidant activities. However caution should be taken in its use as it
has potentials to increase LDL.
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Keywords
Parquetina nigrescens, anaemia, white blood cells, superoxide dismutase, lowdensity lipoprotein
Citation
Owoyele B V, Oyelowo O T, Biliaminu S A, Alaran O N, Alimi S A, Saliu R S. Hematological and biochemical studies on Parquetina nigrescens root extract in albino rats. Journal of Applied Pharmaceutical Science. 2011 Dec; 1(10): 176-179.