Aqueous Extract of Combretum dolichopentalum Leaf - a Potent Inhibitor of Carbon Tetrachloride Induced Hepatotoxicity in Rats.
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Date
2011-12
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Abstract
The aqueous extract of Combretum dolichopentalum leaves were evaluated for its
protective activity against CCl4- induced liver damage. The concentration of 250 and 500 mg/kg
b.w of C. dolichopentalum leaf extract were administered to different group of rats prior to CCl4
administration. Both 250 and 500 mg/kg of the extract significantly (P<0.05) reduced the activity
of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase when compared
to rats administered CCl4 only. Also the concentration of non-enzyme markers of hepatic
dysfunction such as total bilirubin and lipid peroxidation product-malonyldialdehyde was reduced
by C. dolichopentalum. But the concentration of total protein and total cholesterol was increased
when compared to rats administered CCl4 only. This finding suggests that C. dolichopentalum
leaves possessed rich hepatoprotective principles against CCl4 induced toxicity of the liver.
Description
Keywords
Combretum dolichopentalum, hepatotoxicity, protection, inhibitor
Citation
Kalu F N, Ogugua V N, Ujowundu C O, Nwaoguikpe R N. Aqueous Extract of Combretum dolichopentalum Leaf - a Potent Inhibitor of Carbon Tetrachloride Induced Hepatotoxicity in Rats. Journal of Applied Pharmaceutical Science. 2011 Dec; 1(10): 114-117.