Chemoprotective Potentials of Ocimum gratissimum in Diesel Petroleum induced Hepatotoxicity in Albino Wistar Rats.
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Date
2011-12
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Abstract
This study evaluated the effect of diesel petroleum intoxication in rats and the ability of
phytochemicals and antioxidant content of Ocimum gratissimum to ameliorate such toxicity.
Toxicity in rat was induced by administering 4 ml/kg body weight of diesel in the test rats except
control. The intoxication and treatment with 20 % O. gratissimum supplemented diet was for 7
days. Serum liver function markers, Oxidative stress markers and lipid profile were estimated.
Diesel induced hepatotoxicity was characterized by significant (p < 0.05) decrease in serum
protein concentration and oxidative enzymes activities. Also increase in activities of liver function
enzymes and Cholesterol was observed. The group of rats which diet was supplemented with O.
gratissimum showed significant (p< 0.05) improvement in the concentration of serum proteins and
decrease in the activities of liver function enzymes. Similarly the activities of oxidative enzymes
significantly (p<0.05) increased, compared to the untreated rats. These results indicate a
chemoprotective ability of this Nigerian indigenous spice.
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Keywords
Hepatotoxicity, diesel, liver enzymes, oxidative stress, antioxidants
Citation
Ujowundu C O, Nwokedinobi N, Kalu F N, Nwaoguikpe R N, Okechukwu R I. Chemoprotective Potentials of Ocimum gratissimum in Diesel Petroleum induced Hepatotoxicity in Albino Wistar Rats. Journal of Applied Pharmaceutical Science. 2011 Dec; 1(10): 56-61.