Ginger extract protects metalaxyl-induced histomorphological and histochemical alterations in testes of albino mice.
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Date
2011-12
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Abstract
Metalaxyl is a benzenoid fungicide used to control soil-borne fungal diseases on fruits,
cotton, soybean, ornamental and grasses. Ginger (Zingiber officinale) is example of
botanicals which showed many pharmacological effects. The present study investigated the
protective effect of ginger extract on metalaxyl-induced testicular abnormalities in mice. Treating
animals with metalaxyl caused significant decrease in diameters and germinal epithelial heights of
the seminiferous tubules. Histological results revealed that the spermatogenic cells were
degenerated and exfoliated in the lumen of the tubules. Inhibition of spermatogenesis was
recorded after 6 weeks of treatment with metalaxyl. Histochemical results showed decrease of
carbohydrates and total proteins in the testicular tissue. Moreover, metalaxyl led to increase of
sperm head abnormalities. Co-administration of aqueous extract of ginger improved the
histological as well as the histochemical alterations induced by metalaxyl. This may be attributed
to the antioxidant properties of ginger constituents.
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Keywords
Metalaxyl, Testis, Ginger, Histology
Citation
Sakr Saber A, Shalaby Somya Y. Ginger extract protects metalaxyl-induced histomorphological and histochemical alterations in testes of albino mice. Journal of Applied Pharmaceutical Science. 2011 Dec; 1(10): 36-42.