Assessment of antibacterial, thrombolytic and cytotoxic potential of Cassia alata seed oil.
Loading...
Date
2011-11
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Cassia alata is a pan tropical shrub. It has been reported to have medicinal activities
like laxative effect and active against ringworm, skin diseases and ulcer. The leaf extract of this
plant has shown antibacterial activity. In this study, seed oil extracted from Cassia alata , was
studied for Antibacterial, Thrombolytic and Cytotoxic activity by using in vitro techniques.
Chloroform extract of the seed oil was tested for Antibacterial activity using disc diffusion
method and that extract showed potent antibacterial activity against both Gram(+) and Gram(-)
bacteria. DMSO extract of the seed oil was tested for Brine shrimp lethality bioassay using Brine
shrimp nauplii. The LC50 of DMSO extract of Cassia alata seed oil was found to be 250μg/ml,
indicates that the oil has moderate pharmacological action. The DMSO extract of the seed oil was
also tested for in vitro thrombolytic activity. The extract showed reasonable thrombolytic activity
against negative control (water).Further investigation on the plant is required to confirm their
pharmacological activity and thereby utilizing them as useful medicinal plant.
Description
Keywords
Cassia alata, Cytotoxicity, Oil, Thrombolytic, Streptokinase, Antibacterial
Citation
Mannan Adnan, Kawser Md. Junaate, Ahmed A M Abu, Islam Nazneen Naher, Alam S M Murshidul, Emon Mohammad Asif Emran Khan, Gupta Shipan Das. Assessment of antibacterial, thrombolytic and cytotoxic potential of Cassia alata seed oil. Journal of Applied Pharmaceutical Science. 2011 Nov; 1(9): 56-59.