Formulation and Evaluation of Lisinopril Dihydrate Transdermal Proniosomal Gels.
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Date
2011-10
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Abstract
In the present study transdermal Lisinopril proniosomal gels was formulated by using
Lecithin, Cholesterol as encapsulating agents, Surfactant, Span and permeation enhancers. The
study methodology encompasses compatibility studies using FTIR spectra, evaluation of
proniosomal gels for pH determination, Viscosity, Vesicle size analysis, rate of spontaneity,
encapsulation efficiency, in vitro skin permeation studies and stability studies. The preliminary
compatibility studies conducted revealed that there no interaction between Lisinopril and
excipients which was as evident from FTIR spectral studies. The physical characterization of
proniosomal gels was found to be within the acceptable limits. It was observed that the gel
formulations showed good spreadability and viscosity. Determination of vesicle size was found
to be 20.10-26.23μm. The proniosomes showed spherical and homogenous structure in optical
microscopy. All formulations showed zero order drug release by diffusion mechanism. The
stability studies showed that proniosomal gels were stable at 4 to 80C and 25±20C. The above
results indicated that the proniosomal gels of could be formulated for controlled release of
Lisinopril. The proniosomal gels are suitable for Lisinopril once a day controlled release
formulation.
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Keywords
Lisinopril, Pronoisomes, Lecithin, Cholesterol, Transdermal gel
Citation
Ahmad S Shamsheer, Sabareesh M, Khan Patan Rafi, Krishna P Sai, Sudheer B. Formulation and Evaluation of Lisinopril Dihydrate Transdermal Proniosomal Gels. Journal of Applied Pharmaceutical Science. 2011 Oct; 1(8): 181-185.