Evaluation of Kollidon SR based Ketorolac Tromethamine Loaded Transdermal Film.
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Date
2011-10
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Abstract
The present study concerns the development of polymeric films of Ketorolac
tromethamine by solvent casting method to explore the possibilities of using kollidon SR as a
transdermal drug delivery system. Ketorolac tromethamine was used as a model drug &
incorporated in low doses. The films were prepared by using various amounts of Kollidon SR to
prolong the drug release with localized action. Some films were also prepared containing certain
percent of PEG-6000 along with the drug & polymer. The prepared polymeric films were
evaluated for various parameters like weight uniformity, flatness, % elongation, surface pH,
uniformity of drug content, in-vitro dissolution studies. The drug-polymer ratio was found to
influence the drug release. The rate of drug release decreased with increased polymer
concentration. About 10% increased in polymer concentration causes 50% decreased drug
release. All the formulation followed Higuchian kinetics & the mechanism of release was
diffusion mediated. When PEG-6000 was used as a channeling agent in this formulation drug
release was increased accordingly but higher concentration of PEG-6000 results in decreasing
release rate of drug because of increasing viscosity of the matrix channels.
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Keywords
Ketorolac Tromethamine, Transdermal drug delivery system, Transdermal film, Kollidon SR, PEG-6000
Citation
Bhatta Rita, Hossain Mohammad Salim. Evaluation of Kollidon SR based Ketorolac Tromethamine Loaded Transdermal Film. Journal of Applied Pharmaceutical Science. 2011 Oct; 1(8): 123-127.