Effect of aqueous extract of Terminalia catappa leaves on the glycaemia of rabbits.
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Date
2011-10
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Abstract
Diabetes is a disease which affects 5% of Côte-d’Ivoire population. This is a worrying
prevalence rate. Our search for means of fighting this affection made us to develop an herbal
medicine from decoction of Terminalia catappa leaves. During the experience we carried out,
rabbits received, orally, a solution of glucose (4 g/l). As treatment, the hyperglycaemic rabbits
were given, glibenclamide (0.25 mg/ml) and herbal medicine to drink, 0.6 ml per 20 grams of
body weight. Before administration of glucose overload, the animals had a basal glycaemia of
1.11 g/l. The not treated rabbits’ glycaemia increased and reached 1.39 g/l. The oral
administration of glibenclamide lowers blood sugar at 0.86 g/l, after 180 minutes. At 2.5 mg/ml,
the herbal medicine does not induce a significant hypoglycaemic effect. At 10 mg/ml, it
decreases the hyperglycaemia to 1.05 g/l. At 40 mg/ml, it induces a significant decrease in blood
glucose. A fall of 30% was observed. At 40 mg/ml, its effect on hyperglycaemic rabbits is
compared to glibenclamide (0.25 mg/ml). The glibenclamide exerts on normoglycaemic rabbits a
significant basal glucose-lowering effect unlike herbal medicine. The herbal medicine appears
like an antidiabetic and produces its hypoglycaemic effect mainly through alkaloids, sterols or
triterpens.
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Keywords
Côte-d’Ivoire, Diabetes, Ethnopharmacology, Medicinal plants, Traditional Healers
Citation
Koffi Nguessan, Yvette Fofie NGuessan Bra, Noel Zirihi Guede. Effect of aqueous extract of Terminalia catappa leaves on the glycaemia of rabbits. Journal of Applied Pharmaceutical Science. 2011 Oct; 1(8): 59-64.