Enhancement of oral bioavailability and solid dispersion: A review.
Loading...
Date
2011-09
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Improving oral bioavailability of drugs those given as solid dosage forms remains a
challenge for the formulation scientists due to solubility problems. Most of the newly invented
chemical entities are poorly water soluble. As a result formulating them as oral solid dosage forms
is a hurdle to the specialists. Many techniques have been exercised to improve oral bioavailability
of drugs. Among several methods, solid dispersion has attracted attention of the researchers for
previous 50 years. Different formulation strategies have been taken to prepare solid dispersions. It
is evident that solid dispersions improve solubility of drug particles thus enhancing dissolution
characteristics of drugs they increase the oral bioavailability. This review paper will focus on
different aspects of solid dispersion preparation; their advantages, major challenges and
preparation methods.
Description
Keywords
Bioavailability, Solubility, Hot melt extrusion, Carrier, Biopharmaceutical classification, Hot-spin-melting
Citation
Saffoon Nadia, Uddin Riaz, Huda Naz Hasan, Sutradhar Kumar Bishwajit. Enhancement of oral bioavailability and solid dispersion: A review. Journal of Applied Pharmaceutical Science. 2011 Sept; 1(7): 13-20.