Evaluation of Antidiarrhoeal activity of extract from roots of Rumex hastatus (Family: Polygonaceae) on experimental animals.
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Date
2011-08
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Abstract
Rumex hastatus is fairly common small shrub, growing on dry slopes, rocks and walls
between 700-2500 m, typically in North Indian hill station. Roots of Rumex hastatus have been
used in Ayurveda and other folk medicines for the treatment of diarrhoea. To justify its folklore,
present study was undertaken to investigate the antidiarrhoeal activity of the ethanolic extract
from the roots of Rumex hastatus (EERH). Preliminary phytochemical screening, acute toxicity
study and antidiarrhoeal activity of were studied on castor oil induced diarrhoea and normal
gastrointestinal models of rats at 100, 150 and 200mg/kg body weight. The preliminary
phytochemical screening of the ethanolic extract from the roots of Rumex hastatus (EERH) results
with the presence of anthraquinone glycoside, tannins, flavonoids etc., LD50> 2000mg/kg. The
doses of EERH significantly decreased (P<0.001) the total number of diarrhoeal faeces. PI
decreases doses dependentally (100, 150 and 200mg/kg orally) of EERH and was comparable
with standard drug atropine sulphate. Conclusively, EERH has the antidiarrhoeal activity in
experimental rats.
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Keywords
Rumex hastatus, Polygonaceae, Loperamide, Atropine
Citation
Shakuntala, Bharti Pushp, Sachan Neetu, Chandra Phool, Gahlot Kavita. Evaluation of Antidiarrhoeal activity of extract from roots of Rumex hastatus (Family: Polygonaceae) on experimental animals. Journal of Applied Pharmaceutical Science. 2011 Aug; 1(6): 182-185.