Formulation and evaluation of orally disintegrating tablet containing tramadol hydrochloride by mass extrusion technique.
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Date
2011-08
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Abstract
Orally disintegrating tablets are gaining popularity over conventional tablets due to
their convience in administration and suitability for patients. The purpose of this research was to
mask the intensely bitter taste of tramadol hydrochloride and to prepare orally disintegrating
tablets for achievement of quick onset of action of the drug. Trammadol hydrochloride is an
analgesic which has been proved to be efficient in managing relief from pain and including pain
after surgery. In the present study an attempt has been made to prepare bitterless orally
disintegrating tablet of Tramadol Hydrochloride using Eudragit E 100 as a taste masking agent.
Mass extrusion was the technique used for preparing taste masked granules and tablet was
prepared with using superdisintegrants like crospovidone, croscarmellose sodium and sodium
starch glycolate, were prepared blend and evaluated for the pre-compression parameters such as
bulk density, compressibility, angle of repose etc. The prepared batches of tablets were
evaluated for hardness, weight variation, friability, drug content, disintegration time and in-vitro
dissolution profile and found satisfactory. Among the formulations containing Crospovidone
was least and tablets showed fastest disintegration. The drug release from orally disintegrating
tablets increased with increasing concentration of superdisintegrants and was found to be highest
with formulations containing Crospovidone. Thus results conclusively demonstrated successful
masking of taste and fastest disintegration of the formulated tablets in oral cavity.
Description
Keywords
Tramadol hydrochloride, Superdisintegrants, Mass extrusion, Orally disinintegrating tablets
Citation
Patil Mansing G, Kakade Suhas M, Pathade Sandhya G. Formulation and evaluation of orally disintegrating tablet containing tramadol hydrochloride by mass extrusion technique. 178-181.